Lookman, who was recently nominated for the 2024 Ballon d’Or awards, scored in the first and second half of the game at the Godswill Akpabio International Stadium in Uyo, the Akwa Ibom State capital.
Osimhen, on the other hand, came off the bench to score a goal for the Super Eagles.
The Super Eagles are in Group D of the AFCON 2025 qualifying table with Benin Republic, Libya, and Rwanda.
The six-match qualifying matches have been scheduled for September, October, and November.