Another six people were wounded in the serial collisions and rescue efforts were ongoing, state media said.
The accident occurred at around 7am on an overpass in the Tongchuan section of the motorway, the Shaanxi Provincial Emergency Management Office said in a statement.
A report from state broadcaster CCTV said that the accident involved a tanker which was carrying 34 tonnes of Methanol, a flammable chemical element.
Officials said the fire did not spread to the tank truck.
Footage filmed by an eyewitness shows the road engulfed in raging flames, which were burning through wrecked vehicles.
Authorities dispatched 16 fire engines and 105 firefighters to the scene, and the blaze was ‘brought under control’ about an hour and 40 minutes later, CCTV wrote.
Rescuers were still searching for survivors when the fire was put out.
Daily Mail UK