Home Health Long-acting version of Baxter’s hemophilia drug succeeds in study

Long-acting version of Baxter’s hemophilia drug succeeds in study

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Baxter's hemophilia drugBaxter International Inc said a more potent version of its flagship blood disorder drug Advate met the main goal in a late-stage study.

The experimental drug, BAX 855, was being tested as a preventive therapy and an on-demand treatment in 138 previously treated adolescent and adult hemophilia A patients.

The trial’s main goal was to reduce bleeding rates compared with on-demand treatment.

Hemophilia A, also called classic hemophilia, is a genetic disorder caused by missing or defective factor VIII, a clotting protein.

Patients in the twice-weekly prophylaxis, or preventive, arm of the trial experienced a 95 percent reduction in median yearly bleeding rates compared with those in the on-demand arm, Baxter said.

The company plans to apply for U.S. marketing approval for the drug before the end of the year and said it would begin another late-stage study to test BAX 855 in previously treated patients under the age of 12.

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Baxter raised the forecast for its hemophilia franchise in July, despite the potential for competition from Biogen Idec Inc’s long-acting treatment Eloctate, which the U.S. Food and Drug Administration approved in June.

BAX 855 is an extended-release version of Advate, which was first approved over a decade ago and is currently sold in 64 countries.

The experimental drug uses Nektar Therapeutics’ proprietary technology to extend the duration of activity of proteins in the body.

Deerfield, Illinois-based Baxter’s stock was up about 1.2 percent on the New York Stock Exchange on Thursday. (Reuters)

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