Merrimack shares rise as cancer drug combo improves survival




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Merrimack Pharmaceuticals Inc said its lead experimental drug when used as a combination the overall survival rate in patients with metastatic pancreatic cancer, doubling its shares in premarket trading.

Merrimack said a combination of its drug, MM-398, and others showed an overall survival of 6.1 months, compared with 4.2 months shown by the two drugs alone.

The said on Thursday it would apply for a U.S. marketing approval for the combination this year.

The late-stage study testing the drug in patients who were earlier treated with chemotherapy drug gemcitabine.

The trial tested MM-398 in combination with another chemotherapy drug 5-fluorouracil (5-FU) and leucovorin, which helps enhance 5-FU’s effectiveness.

Merrimack said its drug showed an overall survival of 4.9 months when used alone, which not statistically significant.

The said the most common serious adverse events in patients given the combination were an abnormally low count of a type of white blood cells, fatigue, diarrhea and vomiting.

Merrimack said patients taking only MM-398 experienced a higher level of adverse events than those who received the drug combination.

About 46,420 new cases of pancreatic cancer will occur in the States in 2014, according to the American Cancer Society.

The is also testing the drug as a treatment for colorectal cancer, a type of brain tumor and a rare form of bone cancer.