Police officers Benjamin Deen, 34, and Liquori Tate, 25, were shot Saturday and taken to hospital where they were confirmed dead, The Clarion-Ledger newspaper reported, citing Forrest County Coroner Butch Benedict.
Officials did not give details on the motive of the attack but said the suspects, Curtis Banks, 26, and Marvin Banks, 29, were arrested early Sunday morning, ending an hours-long manhunt, according to the newspaper.
The killings come in the wake of another police shooting in New York, where plainclothes officer Brian Moore, 25, was shot in the head and died Monday.
Hattiesburg Mayor Johnny DuPree decried the latest killings.
The newspaper said that one of the officers pulled a car over Saturday evening, approached the vehicle, and was joined by a second officer before shots were fired.
One of the suspects allegedly fled in a police vehicle, which was later found abandoned.
A neighboring police force in Oxford, Mississippi mourned the slain officers.
“Both Hattiesburg Police Officers have died. Terrible. Prayers to the entire community and families,” the Oxford force said on Twitter.
The Clarion-Ledger said it was the first police killing in Hattiesburg in 30 years.
The deaths come at a time of racial tension and protests over police brutality, most recently in the case of a black youth who died April 19 from injuries suffered while in police custody in Baltimore.