World’s first malaria vaccine to be used in Africa

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The world’s first malaria vaccine, produced by GlaxoSmithKline, could be approved by international regulators for use in Africa from October.

The final trial data showed that the shoe, called RTS,S offered partial for children for four years.

It will be the first licensed human vaccine against a parasitic , and could help prevent millions of of malaria, which currently kills more 600,000 people a year.

have long hoped scientists would be able develop an effective malaria vaccine, and researchers at the British drug maker, GSK, have been working on RTS, S for 30 years.

Earlier trial data released in 2011 and 2012 dampened the hopes that this shot would be the final answer wiping malaria.

Then, it showed it only reduced episodes of malaria in aged six weeks to 12 weeks by 27 per cent, and by around 46 per cent in children aged five to 17 months.

But the final stage follow- data published in the Lancet journal showed that vaccinated children continued to be protected four years on, though at a declining rate – an important factor, given the prevalence of the and rates of were stronger with a booster shot.

“In spite of the falling efficacy over time, there is still a clear benefit from RTS,S,” said Brian Greenwood, a professor at the London School of Hygiene & Tropical Medicine who worked on the study.

He said an average 1,363 of clinical malaria were prevented over four years for every 1,000 children vaccinated, or 1,774 with a booster shot.

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“The children would normally be expected to have had several of infection over that period.

In , over three years of follow-, an average 558 cases were prevented for every 1,000 vaccinated, and 983 cases in those who got a booster.

“Given that there were an estimated 198 million malaria cases in 2013, this level of efficacy potentially translates into millions of cases of malaria in children being prevented,” Greenwood said.

GSK submitted an application in July 2014 for regulatory approval by the European Medicines Agency for RTS, S and is expecting a decision within a few months.

“If it gets a licence, the World Health Organisation could recommend it for use “as early as October this year,”Greenwood said.

say RTS, S will be only one among several weapons against malaria, alongside insecticide-treated bed nets, rapid diagnostic tests and anti-malarial drugs.

RTS,S was co-developed by GSK and the non-profit PATH Malaria Vaccine , with funding from the & Melinda Gates . (NAN)